ENPP3 - ectonucleotide pyrophosphatase/phosphodiesterase 3 Gene

Also Known as B10; NPP3; PDNP3; CD203c; PD-IBETA

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5169

About ENPP3

Cytogenetic location: 6q23.2 Genomic coordinates (GRCh38): 6:131,637,302-131,747,410 (from NCBI)

This gene has 7 transcripts (splice variants), 146 orthologues and 6 paralogues. Biased expression in small intestine (RPKM 19.6), duodenum (RPKM 6.7) and 6 other tissues.

Summary

The protein encoded by this gene belongs to a series of ectoenzymes that are involved in hydrolysis of extracellular nucleotides. These ectoenzymes possess ATPase and ATP pyrophosphatase activities and are type II transmembrane proteins. Expression of the related rat mRNA has been found in a subset of immature glial cells and in the alimentary tract. The corresponding rat protein has been detected in the pancreas, small intestine, colon, and liver. The human mRNA is expressed in glioma cells, prostate, and uterus. Expression of the human protein has been detected in uterus, basophils, and mast cells. Two transcript variants, one protein coding and the Other non-protein coding, have been found for this gene. [provided by RefSeq, Oct 2015]

ENPP3 Products (1)

mRNA	Protein	Name
NM_005021.5	NP_005012.2	ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables bis(5'-adenosyl)-pentaphosphatase activity	IDA IDA: Inferred from direct assay	12846830	GOA
enables bis(5'-adenosyl)-triphosphatase activity	IDA IDA: Inferred from direct assay	12846830	GOA
enables bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity	IDA IDA: Inferred from direct assay	12846830	GOA
enables calcium ion binding	IDA IDA: Inferred from direct assay	29717535	GOA
enables nucleoside triphosphate diphosphatase activity	IDA IDA: Inferred from direct assay	10513816	GOA
enables phosphodiesterase I activity	IMP IMP: Inferred from mutant phenotype	11342463	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	29717535	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in ATP metabolic process	IDA IDA: Inferred from direct assay	29717535	GOA
NOT involved in inorganic diphosphate transport	IDA IDA: Inferred from direct assay	10513816	GOA
involved in nucleoside triphosphate catabolic process	IDA IDA: Inferred from direct assay	10513816	GOA
involved in phosphate-containing compound metabolic process	IDA IDA: Inferred from direct assay	10513816	GOA
involved in pyrimidine nucleotide metabolic process	IMP IMP: Inferred from mutant phenotype	11342463	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	11342463	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	10513816	GOA
is active in plasma membrane	IDA IDA: Inferred from direct assay	12846830	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ENPP3 Protein Structure

Somatomedin_B

Phosphodiest

Endonuclease_NS

0
200
400
600
800
875 a.a.

Protein Preferred Names	Protein Names
ectonucleotide pyrophosphatase/phosphodiesterase family member 3	dJ1005H11.3 (phosphodiesterase I/nucleotide pyrophosphatase 3)

Recombinant ENPP3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77925	ENPP-3 Protein, Human (Biotinylated, HEK293, His-Avi)	O14638 (L48-I875)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P77926	ENPP-3 Protein, Human (110a.a, HEK293, His-Avi)	O14638 (L48-D157)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P77927	ENPP-3 Protein, Human (Biotinylated, 110a.a, HEK293, His-Avi)	O14638 (L48-D157)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P77928	ENPP-3 Protein, Human (318a.a, HEK293, His)	O14638 (K558-I875)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P700410	ENPP-3 Protein, Human (HEK293, His)	O14638 (L48-I875)	≥ 95%, as determined by reducing SDS-PAGE.

ENPP3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83803	CD203C Antibody (YA3500)	IHC-P, FC, ELISA	Human
HY-P83803A	CD203C Antibody (YA3500)(PBS only)	IHC-P, FC, ELISA	Human

Related Diseases

Diseases	Alias
Amoxicillin Allergy
Beta-Lactam Allergy
Chronic Urticaria	Urticaria Chronic Chronic Spontaneous Urticaria Chronic Ordinary Urticaria
Apricot Allergy	Prunus Armeniaca Fruit Allergy
Co-Trimoxazole Allergy	Bactrim Allergy Cotrimoxazol Allergy Tmp/Smx Allergy Trimethoprim/Sulfamethoxazole Allergy
Chronic Spontaneous Urticaria	Chronic Idiopathic Urticaria
Cephalosporin Allergy
Crab Allergy	Green Mud Crab Allergy Scylla Paramamosain Allergy
Chlorhexidine Allergy
Acute Basophilic Leukemia
Ceftazidime Allergy	Fortaz Allergy Tazicef Allergy
Diclofenac Allergy	Voltaren Allergy
Optic Atrophy 10 With Or Without Ataxia, Mental Retardation, And Seizures	OPA10 Optic Atrophy 10 With Or Without Ataxia, Intellectual Disability, And Seizures Optic Atrophy 10 Atrophy, Optic, Type 10, With/Without Ataxia, Mental Retardation, And Seizures
Drug Allergy	Allergy Drug Drug Allergies
Oxirane Allergy	Ethylene Oxide Allergy Eto Allergy
Physical Urticaria	Symptomatic Dermographism
Urticaria	Nettle Rash Hives Wheal Urticaria Nos
Mastocytosis	Mast Cell Disease Mast Cell Hyperplasia Urticaria Pigmentosa Malignant Mastocytoma Malignant Mast Cell Tumours Malignant Mastocytosis
Peach Allergy	Prunus Persica Fruit Allergy
Nut Allergy	Nut Allergic Reaction Nut Hypersensitivity Allergy To Nuts Allergy Nut
Dermatographia	Dermatographic Urticaria Dermographism Symptomatic Dermographism Urticaria Factitia Factitious Urticaria Dermatographism
Carbapenem Allergy
Cholinergic Urticaria
Pollen Allergy	Hay Fever
Fruit Allergy	Allergy To Fruit
Legume Allergy	Fabaceae Allergy
Egg Allergy	Allergy To Eggs Allergies Egg Egg Hypersensitivity
Latex Allergy
Aspergillosis	Aspergillosis, Susceptibility To Infection Due To Aspergillus Aspergilloma Aspergillus Nodule Simple Aspergilloma Aspergillus Aspergillus Flavus Infection Aspergillus Fumigatus Infection Aspergillus Infection Infection By Aspergillus Fumigatus Intracavitary Aspergillus Fungus Ball Aspergillus Terreus
Peanut Allergy	Allergy To Peanuts Peanut Allergic Reaction Allergies Peanut Peanut Hypersensitivity
Wheat Allergy	Wheat Allergic Reaction Wheat Hypersensitivity Allergy To Wheat Allergy Wheat
Penicillin Allergy	Allergy To Penicillin
Arterial Calcification Of Infancy	Idiopathic Infantile Arterial Calcification Generalized Arterial Calcification Of Infancy Iiac Occlusive Infantile Arteriopathy Infantile Arteriosclerosis Gaci Idiopathic Obliterative Arteriopathy Generalized Arterial Calcification In Infancy Arteriopathia Calcificans Infantum Diffuse Arterial Calcifying Elastopathy Of Infancy Infantile Calcifying Arteriopathy Medial Coronary Sclerosis Of Infancy Coronary Sclerosis, Medial, Of Infancy Calcification, Arterial, Generalized, Infancy
Solitary Mastocytoma Of The Skin	Cutaneous Solitary Mastocytoma Skin Mastocytoma Solitary Mastocytoma Solitary Mastocytoma Of Skin Mastocytoma, Skin
Food Allergy	Food Hypersensitivity Food Allergies Allergy Food Food Allergen-Induced Hypersensitivity
Aggressive Systemic Mastocytosis	Asm Lymphadenopathic Mastocytosis With Eosinophilia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (12)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-169804	ENPP3 Inhibitor 1	Inhibitor	99.43%	Unkown
HY-171544	AGS-16C3F		99.81%	Unkown
HY-158791	Enpp-1-IN-21	Inhibitor	99.07%	Unkown
HY-147998	Enpp-1-IN-13	Inhibitor	/	Unkown
HY-172527	CD73-IN-20	Inhibitor	/	Unkown
HY-172528	Enpp-1/3-IN-1	Inhibitor	/	Unkown
HY-175478	Enpp-1-IN-27		/	Unkown
HY-181667	Enpp-1-IN-30	Inhibitor	/	Unkown
HY-184200	Enpp-1-IN-32		/	Unkown
HY-RS04389	ENPP3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17607	Enpp3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24067	Enpp3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Bioactive MoleculesInhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991706	Nelvutamig	Inhibitor	97.76%	Unkown
HY-P991705	Nebaprubart	Inhibitor	96.95%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ENPP3	VGNC	VGNC:28506
Mus musculus	ENPP3	MGD	MGI:2143702
Canis familiaris	ENPP3	VGNC	VGNC:40376
Macaca mulatta	ENPP3	VGNC	VGNC:72224
Felis catus	ENPP3	VGNC	VGNC:61874
Rattus norvegicus	ENPP3	RGD	RGD:708511
Others	ENPP3	NCBI